4/30/2023 0 Comments Low intensity statin![]() The main outcomes were 30-day and 1-year all-cause mortality. In 14% of patients, the statin dose was deintensified during their admission for stroke or TIA. After hospitalization, 34.1% remained off of statin, 6.7% were on low-intensity statin, 39.3% were on moderate-intensity statin, and 19.9% were on high-intensity statin. The groups were described as goal-to-goal, low-to-goal, deintensification, none-to-none, none-to-low, and low-to-low.Īt the time of admission, half of patients were not on any statin. With this in mind, they divided their patients into 6 practical groups based on the pre-hospitalization statin and post-hospitalization statin. Statins were categorized based on potency, and moderate-high intensity statins were considered “at goal.” Using the databases available, they looked at the statin prescribed within the 120 days before the stroke or TIA and the statin prescribed up to 7 days after discharge for stroke or TIA. Their cohort of patients was 96.3% male, 71.1% White, and 34.9% smokers. After excluding those who were transferred out of the VA system, died during hospitalization, left against medical advice, were discharged to hospice, or allergic to statins, 9,380 patients were left for review. This study looked at 10,871 patients with a primary diagnosis of acute ischemic stroke or TIA who presented to the ER or were admitted during the fiscal year of 2011 at 134 VA centers across the United States. In those with ischemic stroke or TIA who have evidence of atherosclerotic disease, LDL-C lowering to <70mg/dL is recommended with statin and, if needed, ezetimibe, though a specific dose or intensity of statin is not specified. High-intensity statin and LDL-C goal 100mg/dL. Optimizing statin therapy in patients after stroke or TIA is an important component of secondary stroke prevention. Deintensification or No Statin Treatment Is Associated with Higher Mortality in Patients With Ischemic Stroke or Transient Ischemic Attack. Greenway, JL, Hu X, Bravata DM, Phadke MA, Baye FM, Myers LJ, Concato J, Zillich AJ, Reeves MJ, Sico JJ.
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